Sex-specific impact on disease outcome and the mutational landscape in essential thrombocythemia:A retrospective cohort study  

作　　者：Jia Chen Huan Dong Yang Li Ting Sun Rongfeng Fu Xiaofan Liu Feng Xue Wei Liu Yunfei Chen Mankai Ju Xinyue Dai Ying Chi Wentian Wang Huiyuan Li Renchi Yang Lei Zhang 

机构地区：[1]State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin Key Laboratory of Gene Therapy for Blood Diseases,CAMS Key Laboratory of Gene Therapy for Blood Diseases,Tianjin 300020,China [2]Tianjin Institutes of Health Science,Tianjin 301600,China [3]School of Population Medicine and Public Health,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China

出　　处：《Chinese Medical Journal》2024年第12期1495-1497,共3页中华医学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82270152,and 82100151);CAMS Innovation Fund for Medical Sciences(CIFMS)(Nos.2021-I2M-1-073,2021-I2M-1-003,and 2022-I2M-2-003);Clinical Research Fund of National Center for Clinical Medical Research of Hematology Diseases(No.2023NCRCA0109)

摘　　要：To the Editor:Male sex has been confirmed to be an independent risk factor for survival in patients with essential thrombocythemia(ET).[1,2]Sexual dimorphism significantly contributes to patient heterogeneity,and adopting a sex-informed perspective has emerged as a pioneering paradigm in the field of precision medicine.Investigating the spectrum of sex disparities among patients diagnosed with ET holds substantial scientific justification.Furthermore,sex influences the presentation,disease phenotypes,symptom expression,and clinical outcomes of classical Philadelphia chromosome-negative myeloproliferative neoplasm(MPN).[3,4]The objective of our study was to comprehensively elucidate the impact of sex on ET by exploring disease genotype and phenotype as well as clinical outcomes.

关 键 词：IMPACT LANDSCAPE holds 

分 类 号：R558.3[医药卫生—血液循环系统疾病]