云南不明原因猝死肠道病毒感染研究进展与展望  

Research progress and prospects on enterovirus infection in Yunnan Unexplained Sudden Death

作　　者：马琳 王跃兵[2] 张勇[3] Ma Lin;Wang Yuebing;Zhang Yong(School of Public Health,Dali University,Dali 671000,China;Yunnan Provincial Key Laboratory of Natural Epidemic Disease Prevention and Control Technology,Yunnan Institute for Endemic Disease Control and Prevention,Dali 671000,China;National Polio Laboratory,WHO WPRO Regional Polio Reference Laboratory,National Health Commission Key Laboratory for Biosecurity,National Health Commission Key Laboratory for Medical Virology,National Key Laboratory of Traceability and Intelligent Decision-making for Infectious Diseases,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]大理大学公共卫生学院,大理671000 [2]云南省地方病防治所,云南省自然疫源性疾病防控技术重点实验室,大理671000 [3]中国疾病预防控制中心病毒病预防控制所,传染病溯源预警和智能决策全国重点实验室,国家卫生健康委员会实验室生物安全重点实验室,世界卫生组织西太平洋区脊髓灰质炎参比实验室,北京102206

出　　处：《中华地方病学杂志》2024年第5期425-430,共6页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81960573);云南省技术创新人才培养对象项目(202405AD350026);云南省科技厅应用基础研究计划青年项目(2018FD111);徐建国院士工作站项目(2019YS08);云南省地方病防治所青年人才资助培养计划(YIEDC-G202104)

摘　　要：云南不明原因猝死病因至今未明,是云南省长期以来危害严重的地方性公共卫生问题。目前,有研究表明,该病由多种病因导致,鉴于以往研究方法有限,迄今对该病的认识还存在一定的局限性。本文对云南不明原因猝死自首次报道以来的病因研究学说进行了系统梳理,详细论述了该病与肠道病毒感染间的相关性,并结合宏基因组二代测序技术作一展望,以期为今后的病因研究提供借鉴和参考。The etiology of Yunnan unexplained sudden death(YUSD)is still unknown,and it has been a serious endemic public health problem in Yunnan Province for a long time.Currently,known studies have shown that this disease is caused by multiple etiological factors.Due to limited study methods in the past,there are still certain limitations in understanding this disease.This article systematically reviews the etiological theories of YUSD since its first report,elaborates on the correlation between this disease and enterovirus infection,and combines metagenomic next-generation sequencing technology to make a prospect,in order to provide reference for future etiological studies.

关 键 词：云南不明原因猝死 病因学 肠道病毒 二代测序 

分 类 号：R512.5[医药卫生—内科学]