Role of mitochondrial dysfunction in kidney disease:Insights from the cGAS-STING signaling pathway  

作　　者：Lu Li Fei Liu Chunyue Feng Zhenjie Chen Nan Zhang Jianhua Mao 

机构地区：[1]Department of Nephrology,Children’s Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou,Zhejiang 310052,China [2]Department of Pediatric Intensive Care Unit,Children’s Hospital,Zhejiang University School of Medicine,National Clinical Research Center for Child Health,Hangzhou,Zhejiang 310052,China

出　　处：《Chinese Medical Journal》2024年第9期1044-1053,共10页中华医学杂志（英文版）

基　　金：supported by a grant from the Zhejiang Provincial Natural Science Foundation of China(No.LY22H050002)

摘　　要：Over the past decade,mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease.However,the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive.The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate(GMP-AMP)synthetase(cGAS)-stimulator of interferon gene(STING)signaling pathway have revealed its involvement in many renal diseases.One of these findings is that mitochondrial DNA(mtDNA)induces inflammatory responses via the cGAS-STING pathway.Herein,we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage,focusing specifically on the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases.Furthermore,we summarize the latest findings of cGAS-STING signaling pathway in cell,with a particular emphasis on its downstream signaling related to kidney diseases.This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway,kidney diseases,and mitochondrial dysfunction.

关 键 词：Mitochondrial dysfunction Mitochondrial DNA cGAS-STING pathway Kidney diseases Chronic kidney disease 

分 类 号：R692[医药卫生—泌尿科学]