Perspectives of genetic management strategy for inherited cardiovascular diseases in China  

作　　者：Yaoyao Zhang Yanjiang Zheng Mengyuan Dai Kaiyu Zhou Lijun Fu Yuxuan Guo Yihua He Fen Li Rui Gao Donghui Zhang Xujie Liu Jie Tian Yimin Hua Yifei Li Lang Qin 

机构地区：[1]Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]Department of Department of Obstetrics and Gynecology,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,China [3]Department of Pediatrics,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,China [4]Department of Cardiology,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China [5]Peking University Health Science Center,School of Basic Medical Sciences,The Institute of Cardiovascular Sciences,Key Laboratory of Molecular Cardiovascular Science of Ministry of Education,Beijing 100191,China [6]Department of Ultrasound,Beijing Anzhen Hospital affiliated to Capital Medical University,Beijing 100029,China [7]State Key Laboratory of Biocatalysis and Enzyme Engineering,School of Life Science,Hubei University,Wuhan,Hubei 430062,China [8]Shenzhen Key Laboratory of Cardiovascular Disease,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Guangdong 518052,China [9]Department of Cardiology,Ministry of Education Key Laboratory of Child Development and Disorders,National Clinical Research Center for Child Health and Disorders(Chongqing),China International Science and Technology Cooperation Base of Child Development and Critical Disorders,Children’s Hospital of Chongqing Medical University,Chongqing 400014,China

出　　处：《Chinese Medical Journal》2024年第8期959-961,共3页中华医学杂志（英文版）

基　　金：Key R&D Program of Sichuan Province of China(No.2021YFQ0061);Science and Technology Department of Sichuan Province(No.2022ZYD0067 and MSGC20230024);Natural Science Foundation of China(Nos.82070324,82001496,and 82270249);Project of Chengdu Science and Technology Bureau(No.2021-YF05-02110-SN);China Postdoctoral Science Foundation(Nos.2020M680149 and 2020T130087ZX)

摘　　要：Inherited cardiovascular diseases(CVDs)threaten human health and pose an enormous economic burden worldwide.Genetic alteration is a major risk factor for many CVDs.These disorders are usually controlled by a pair of alleles,affecting offspring according to the Mendelian principle,regardless of isolated primary damage or secondary injury from other syndromes or deficiency.To date,there are hundreds of inherited CVDs.With advances in nextgeneration sequencing(NGS)technologies,rapid and accurate molecular diagnosis of patients with inherited CVDs is clinically practical.Besides,great improvements have been made in recent years,and targeted therapy and assist devices have been used in clinical practice.Yet there is still no totally efficient strategy for dealing with inherited CVDs.Accordingly.

关 键 词：DIAGNOSIS hundreds dealing 

分 类 号：R54[医药卫生—心血管疾病]