Pathogens of first-episode pulmonary infection in 141 children with chronic granulomatous disease  

作　　者：Hui Liu Shunying Zhao Haiming Yang Jinrong Liu Hui Xu Xiaolei Tang Yuelin Shen Xiaoyan Zhang Xiaohui Wen Yuhong Zhao Ping Chu Huimin Li 

机构地区：[1]Department of Second Respiratory Medicine,National Clinical Research Center for Respiratory Diseases,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China [2]Office of Scientific Research,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China

出　　处：《Chinese Medical Journal》2024年第4期502-504,共3页中华医学杂志（英文版）

基　　金：supported by a grant from the Respiratory Research Project of the National Clinical Research Center for Respiratory Diseases(No.HX2X-202103).

摘　　要：To the Editor:Chronic granulomatous disease(CGD)is an inherited primary immunodeficiency disease characterized by recurrent life-threatening bacterial or fungal infection and tissue granuloma formation.^([1])Pulmonary infection is the most frequent manifestation,affecting nearly 80%of patients,[2]and remains the major cause of morbidity and mortality in patients with CGD.Details of the pathogenic microorganisms responsible for first-episode pulmonary infection provide information on the spectrum of infection in patients with CGD,help guide the empirical choice of antibiotics or antifungal therapy,and contribute to the early identification and management of CGD.Aspergillus is the commonest causative agent of pulmonary infection,but the distribution of other pathogens varies among countries.^([2–5])Few studies have investigated the etiology of pulmonary infection in CGD in a large cohort in China.

关 键 词：GRANULOMA INFECTION MORTALITY 

分 类 号：R725.6[医药卫生—儿科] R446.5[医药卫生—临床医学]