基于复合灵敏度编码的弥散加权成像表观扩散系数直方图鉴别鼻咽癌与鼻咽良性增生的应用价值  

Diagnostic value of apparent diffusion coefficient histograms using multiplexed sensitivity encoding diffusion-weighted imaging for distinguishing nasopharyngeal carcinoma from benign hyperplasia

作　　者：孟铁豹 符劲 刘海彬 刘辉明[1] 何浩强[1] 柯梁汝 谢传淼[1] Meng Tiebao;Fu Jin;Liu Haibin;Liu Huiming;He Haoqiang;Ke Liangru;Xie Chuanmiao(Department of Radiology,Sun Yat-sen University Cancer Center,Guangzhou 510060,China)

机构地区：[1]中山大学肿瘤防治中心影像科,广州510060

出　　处：《中华医学杂志》2024年第6期445-449,共5页National Medical Journal of China

基　　金：国家高性能医疗器械创新中心开放基金(NMED2021MS-01-007)

摘　　要：回顾性分析中山大学肿瘤防治中心2022年5月至2023年7月115例鼻咽肿物患者资料(男78例,女37例,年龄12~78岁),包括鼻咽癌70例和鼻咽良性增生45例。良性增生的复合灵敏度编码的弥散加权成像(MUSE-DWI)表观扩散系数(ADC)直方图均值,中位数,第10、25、75、90百分位数均高于鼻咽癌组(均P<0.05);而ADC直方图峰度和偏度均低于鼻咽癌组(均P<0.05)。采用ADC直方图各参数联合诊断鼻咽癌的受试者工作特征(ROC)曲线下面积为0.812(95%CI:0.732~0.892),灵敏度、特异度和准确率分别为92.86%、57.78%和79.13%。基于MUSE-DWI的ADC直方图参数在鉴别鼻咽癌和良性增生方面具有重要价值。The data of 115 patients with nasopharyngeal masses(78 males and 37 females)aged between 12 and 78 years at the Sun Yat-sen University Cancer Center from May 2022 to July 2023 were retrospectively reviewed,including 70 cases of nasopharyngeal carcinoma and 45 cases of benign hyperplasia.The mean,median,and percentiles(10 th,25 th,75 th,and 90 th)of the apparent diffusion coefficient(ADC)histogram derived from multiplexed sensitivity encoding diffusion-weighted imaging(MUSE-DWI)of the benign hyperplasia group were significantly higher than those of the nasopharyngeal carcinoma group(all P<0.05).Conversely,the kurtosis and skewness of benign hyperplasia group were significantly lower than those of the nasopharyngeal carcinoma group(both P<0.05).The area under receiver operating characteristic(ROC)curve of the combined ADC histogram parameters was 0.812(95%CI:0.732-0.892),and the sensitivity,specificity and accuracy were 92.86%,57.78%and 79.13%,respectively.The current study indicates ADC histogram parameters derived MUSE-DWI exhibit significant discriminatory value between nasopharyngeal carcinoma and benign hyperplasia.

关 键 词：鼻咽肿瘤 磁共振成像 表观扩散系数直方图 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.63[医药卫生—诊断学]