Decreased FEF_(50) as an indicator of comorbid asthma and persistent airflow limitation in patients with chronic rhinosinusitis with nasal polyps:A cross-sectional study  

作　　者：Xuechen Wang Fangyuan Li Chengshuo Wang Kai Huang Shen Shen Ming Wang Jianmin Jin Luo Zhang 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China [2]Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China [3]Beijing Key Laboratory of Nasal Diseases,Beijing Institute of Otolaryngology,Beijing 100005,China [4]Department of Allergy,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China [5]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases,Chinese Academy of Medical Sciences,Beijing 100730,China

出　　处：《Chinese Medical Journal》2024年第3期353-355,共3页中华医学杂志（英文版）

基　　金：supported by grants from national key Research&Development program of China(No.2022YFC2504100);the program for the Changjiang scholars and innovative research team(No.IRT13082);the CAMS innovation fund for medical sciences(No.2019-I2M-5-022);the Capital’s funds for health improvement and research(No.2022-1-1091);the Natural Science Cultivation Fund of Beijing Tongren Hospital(No.2021-YJJ-ZR-014)

摘　　要：To the Editor:While 20–60%of patients with chronic rhinosinusitis with nasal polyps(CRSwNP)have comorbid asthma(known as refractory asthma),asthma is undiagnosed in 25–48%of CRSwNP patients with comorbid asthma._([1])Moreover,the prevalence of persistent airflow limitation(PAL)is high in CRSwNP patients with comorbid asthma.However,the factors indicating comorbid asthma in patients with CRSwNP and reflecting PAL in those with comorbid asthma have not been fully elucidated.Small airway dysfunction(SAD)has been found in CRSwNP patients,even in the absence of asthma;and the severity of SAD in patients with comorbid asthma is correlated with the duration of asthma history._([2])This study therefore aimed to evaluate the clinical characteristics,especially small airway parameters as indicators of comorbid asthma in patients with CRSwNP and of PAL in CRSwNP patients with comorbid asthma.Besides,in order to identify the characteristics of CRSwNP patients with asthma,we also compared the prevalence of SAD and PAL between asthma patients with or without CRSwNP.

关 键 词：ASTHMA PATIENTS MORBID 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]