Angiotensin-converting enzyme 2:virus accomplice or host defender?  

作　　者：Jiyan Wang Hongkai Chang Yaya Qiao Huanran Sun Xichuan Li Shuofeng Yuan Shuai Zhang Changliang Shan 

机构地区：[1]State Key Laboratory of Medicinal Chemical Biology,College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research,Nankai University,Tianjin 300350,China [2]Tianjin Key Laboratory of Animal and Plant Resistance,College of Life Sciences,Tianjin Normal University,Tianjin 300387,China [3]State Key Laboratory of Emerging Infectious Diseases,Carol Yu Centre for Infection,Department of Microbiology,Li Ka Shing Faculty of Medicine,The University of Hong Kong,Pokfulam 999077,Hong Kong Special Administrative Region,China [4]School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China

出　　处：《Journal of Bio-X Research》2023年第3期93-103,共11页生物组学研究杂志（英文）

基　　金：supported by grants from the Natural Science Foundation of Tianjin(21JCZDJC00060 to CS);the National Natural Science Foundation of China(81973356 to CS,81902826 and 81672781 to SZ);the Fundamental Research Funds for the Central Universities of Nankai University(ZB22010404,3206054,63213082,63221331,and 63231108 to CS);the State Key Laboratory of Drug Research(SIMM2105KF-08 to CS);the National Key R&D Program of China(No.2021YFC1712900 to SZ).

摘　　要：Objective:Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has led to social disruptions,mainly because we know too little about SARS-CoV-2.Methods and Results:In this study,we integrated RNA sequencing results and found that SARS-CoV-2 infection alters aerobic glycolysis,the oxidative pentose phosphate pathway(oxiPPP),and DNA replication in lung tissues and cells.However,the direction of metabolic flux and DNA replication are dominated by angiotensin-converting enzyme 2(ACE2),a host cell-expressed viral receptor protein.More interestingly,although hosts with a high expression of ACE2 are more likely to be infected with SARS-CoV-2,the invading virus cannot perform nucleic acid replication well due to the restriction of glucose metabolism,eventually resulting in a prolonged infection cycle or infection failure.Conclusion:Our findings preliminarily explain the reasons for the emergence of asymptomatic infections at an early stage,which will provide assistance for the development of detection methods for diagnosing COVID-19.

关 键 词：ACE2 asymptomatic infection COVID-19 METABOLISM SARS-CoV-2 

分 类 号：R511[医药卫生—内科学]