Association between fresh fruit consumption and the risk of chronic obstructive pulmonary disease-related hospitalization and death in Chinese adults:A prospective cohort study  

作　　者：Xin Huang Jiachen Li Weihua Cao Jun Lyu Yu Guo Pei Pei Qingmei Xia Huaidong Du Yiping Chen Yang Ling Rene Kerosi Rebecca Stevens Xujun Yang Junshi Chen Canqing Yu Zhengming Chen Liming Li on behalf of China Kadoorie Biobank 

机构地区：[1]Department of Epidemiology and Biostatistics,School of Public Health,Peking University Health Science Center,Beijing 100191,China [2]Peking University Center for Public Health and Epidemic Preparedness and Response,Beijing 100191,China [3]Key Laboratory of Molecular Cardiovascular Sciences(Peking University),Ministry of Education,Beijing 100191,China [4]National Clinical Research Center for Cardiovascular Diseases,Fuwai Hospital,Chinese Academy of Medical Sciences,National Center for Cardiovascular Diseases,Beijing 100037,China [5]National Coordinate Center,Chinese Academy of Medical Sciences,Beijing 100730,China [6]Nuffield Department of Population Health,Clinical Trial Service Unit and Epidemiological Studies Unit(CTSU),University of Oxford,Oxford OX37LF,UK [7]Medical Research Council Population Health Research Unit at the University of Oxford,Oxford OX37LF,UK [8]Maiji Center for Disease Control and Prevention,Tianshui,Gansu 741020,China [9]China National Center for Food Safety Risk Assessment,Beijing 100022,China [10]不详

出　　处：《Chinese Medical Journal》2023年第19期2316-2323,共8页中华医学杂志（英文版）

基　　金：supported by grants from the National Key Research&Development Program of China(Nos.2016YFC0900500,2016YFC0900501,2016YFC0900504,and 2016YFC1303904);National Natural Science Foundation of China(Nos.81973125,81941018,91846303,and 91843302)

摘　　要：Background:Existing evidence suggests that fruit consumption is a significant influencing factor for chronic obstructive pulmonary disease(COPD),but this is unclear in the Chinese population.We examined the association of fresh fruit consumption with the risk of COPD-related hospitalization and death in a nationwide,population-based prospective cohort from China.Methods:Between 2004 and 2008,the China Kadoorie Biobank recruited>0.5 million adults aged 30 to 79 years from ten diverse regions across China.After excluding individuals diagnosed with major chronic diseases and prevalent COPD,the prospective analysis included 421,428 participants.Cox regression was used to calculate the hazard ratios(HRs)for the association between fresh fruit consumption and risk of COPD-related hospitalization and death,with adjustment for established and potential confounders.Results:During a mean follow-up of 10.9 years,11,292 COPD hospitalization events and deaths were documented,with an overall incidence rate of 2.47/1000 person-years.Participants who consumed fresh fruit daily had a 22%lower risk of COPD-related hospitalization and death compared with non-consumers(HR=0.78,95%confidence interval[CI]:0.71-0.87).The inverse association between fresh fruit consumption and COPD-related hospitalization and death was stronger among non-current smokers and participants with normal body mass index(BMI)(18.5 kg/m^(2)≤BMI<24.0 kg/m^(2));the corresponding HRs for daily fresh fruit consumption were 0.78(95%CI:0.68-0.89)and 0.69(95%CI:0.59-0.79)compared with their counterparts,respectively.Conclusions:High-frequency fruit consumption was associated with a lower risk of COPD in Chinese adults.Increasing fruit consumption,together with cigarette cessation and weight control,should be considered in the prevention and management of COPD.

关 键 词：Fresh fruit Chronic obstructive pulmonary disease SMOKING Body mass index 

分 类 号：R563[医药卫生—呼吸系统]