Butyrate acts as a G-protein-coupled receptor ligand that prevents high glucose-induced amyloidogenesis in N2a cells through the protein kinase B/glycogen synthase kinase-3β pathway  

作　　者：Yujie Xu Shufang Shan Xiaoyu Wang Lingli Li Liang Ma Jingyuan Xiong Ping Fu Guo Cheng 

机构地区：[1]Department of Pediatrics,Laboratory of Molecular Translational Medicine,Center for Translational Medicine,Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]West China School of Nursing,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [3]Kidney Research Institute,Division of Nephrology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [4]Healthy Food Evaluation Research Center,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Chinese Medical Journal》2023年第19期2368-2370,共3页中华医学杂志（英文版）

基　　金：supported by grants from the Active Health and Aging Technologic Solutions Major Project of the National Key R&D Program(No.2020YFC2006300);the Department of Science and Technology of Sichuan Province(No.2021YJ0156);the West China Nursing Discipline Development Special Fund Project of Sichuan University(No.HXHL20006)

摘　　要：To the Editor:Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are major causes of morbidity and mortality in older individuals,and their epidemiological link generates substantial challenges for the management of these devastating diseases.Abnormal glucose metabolism,accompanied by inhibition of the protein kinase B(Akt)/glycogen synthase kinase-3b(GSK-3b)signaling pathway,is a key factor in amyloid precursor protein(APP)accumulation and amyloid b(Ab)formation in neuronal cells.[1-3]Therefore,activation of the Akt/GSK-3b pathway may be a promising target for AD treatment.

关 键 词：AMYLOID metabolism MORTALITY 

分 类 号：R587.1[医药卫生—内分泌] R749.16[医药卫生—内科学]