Sex hormone-binding globulin,genetic susceptibility,and the risk of type 2 diabetes in men and postmenopausal women  

作　　者：Wen Zhang Haojie Zhang Bin Wang Yuying Wang Ningjian Wang Yingli Lu 

机构地区：[1]Institute and Department of Endocrinology and Metabolism,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

出　　处：《Chinese Medical Journal》2023年第16期1993-1995,共3页中华医学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(No.82120108008);Science and Technology Commission of Shanghai Municipality(Nos.22015810500 and 20015800400)

摘　　要：To the Editor:Type 2 diabetes(T2D)is one of the most common and fastest growing non-communicable diseases worldwide.Sex hormone-binding globulin(SHBG)is a circulating homodimeric glycoprotein that can bind androgens and estrogens with high affinity in blood and regulate their bioavailability.[1]Emerging evidence has shown that low levels of SHBG are associated with T2D.[2]Genetic factors are important factors that affect the development of T2D.However,the combined effect of SHBG and genetic factors on T2D risk is largely unknown.In the current study,we analyzed data from the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)to evaluate whether SHBG levels could interact with genetic predisposition to increase the T2D risk in men and postmenopausal women and examined the joint association of SHBG and genetic predisposition with T2D.

关 键 词：GLOBULIN POSTMENOPAUSAL DIABETES 

分 类 号：R587.1[医药卫生—内分泌]