Analysis of prevailing pertussis strains from different regions in China after the application of acellular vaccines  

作　　者：Yamin Liu Bei Jiang Yu Guo Yuan Gao Jing Qian Chunhua Qie Zhujun Shao Ying Li Qi Wu 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Tianjin Medical University General Hospital,Tianjin 300052,China [2]Institute of Hepatology,Tianjin Second People’s Hospital,Tianjin 300192,China [3]Department of Infectious Disease,Clinical School of the Second People’s Hospital,Tianjin Medical University,Tianjin 300192,China [4]Department of Clinical Laboratory,Nankai Hospital,Tianjin 300100,China [5]National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China [6]State Key Laboratory for Infectious Disease Prevention and Control,Beijing 102206,China [7]Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,Hangzhou,Zhejiang 310005,China

出　　处：《Chinese Medical Journal》2023年第13期1618-1620,共3页中华医学杂志（英文版）

基　　金：Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK059B)

摘　　要：To the Editor:With the extensive uptake of pertussis vaccine,morbidity and mortality related to pertussis have decreased significantly.The application of acellular vaccines(ACVs)occurred later in China than in developed countries;correspondingly,the pertussis resurgence in China also began later.The latest global genotype dynamic prediction model cannot explain the B.pertussis genotype change trend in China.[1]Chinese B.pertussis strains gradually formed their own unique developmental branches.[2]Here,a phylogenetic tree of prevailing B.pertussis strains from three different regions of China was visualized by EvolView(http://www.evolgenius.info/evolview.html).A total of 199 isolated B.pertussis strains were used for the phylogenetic analysis.The B.para-pertussis strain isolated from Tianjin was used as the out-group,and Chinese strain(CS),which is widely used as a vaccine strain for ACV production in China,was used as the reference strain.In particular,we analyzed the multilocus sequence typing(MLST)and macrolide-resistance-conferring gene mutations.

关 键 词：prevailing APPLICATION PERTUSSIS 

分 类 号：R516.6[医药卫生—内科学]