Targeting senescent dermal fibroblasts responsible for hyperactive melanocytes in melasma  

作　　者：Jing Wan Zhikai Liao Bingqi Dong Shan Jiang Tiechi Lei 

机构地区：[1]Department of Dermatology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China

出　　处：《Chinese Medical Journal》2023年第13期1563-1565,共3页中华医学杂志（英文版）

基　　金：National Natural Science Foundation of China(Nos.81972919,82273513)

摘　　要：Melasma(chloasma)is a highly prevalent and cosmetically disfiguring pigmented skin disease that mainly manifests as bilateral irregular brown macules on sun-exposed areas of the face.[1]Although melasma causes no physical discomfort,it poses a significant psychological burden on patients due to distressing cosmetic concerns.The sustained epidermal hypermelanization is a prominent pathological feature of melasma,which is usually considered to result from melanin overproduction by hyperactive melanocytes.[2]However,existing therapeutic interventions that suppress melanocytes and tyrosinase.

关 键 词：cytes SUSTAINED melan 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]