Characteristics of staphylococcal cassette chromosome mec and lugdunin operon genes in the complete genome of Staphylococcus lugdunensis  

作　　者：Shining Fu Yusheng Chen Ke Hu Tian Qin Yukun He Lili Zhao Xinqian Ma Li Chen Wenyi Yu Yan Yu Yu Xie Yifan Wang Donghong Yang Yu Xu Zhancheng Gao 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Peking University People’s Hospital,Beijing 100044,China [2]Department of Pulmonary and Critical Care Medicine,Fujian Provincial Hospital,Fuzhou,Fujian 350000,China [3]Second Division of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China [4]National Institute for Communicable Disease Control and Prevention,State Key Laboratory for Infectious Disease Prevention and Control,Chinese Center for Disease Control and Prevention,Beijing 102206,China [5]Department of Respiratory Medicine,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China [6]Department of Pulmonary and Critical Care Medicine,Beijing Jishuitan Hospital,Beijing 100035,China

出　　处：《Chinese Medical Journal》2023年第11期1367-1369,共3页中华医学杂志（英文版）

基　　金：National Science and Technology Major Project of China(No.2017ZX10103004-006);National Key Research and Development Programme of China(No.2016YFC0903800)

摘　　要：Staphylococcus lugdunensis(S.lugdunensis)is a coagulase-negative Staphylococcus comprising the normal skin microbiota,primarily colonizing the lower abdomen and extremities.[1]S.lugdunensis has attracted substantial attention in recent years since the discovery of lugdunin by Zipperer et al[2]in 2016.Lugdunin is a secondary metabolite synthesized by non-ribosomal peptide synthetase(NRPS)that inhibits the growth of various grampositive bacteria,including methicillin-resistant S.aureus(MRSA),[2]suggesting its potential as an antibiotic.

关 键 词：MEC primarily ABDOMEN 

分 类 号：R378.11[医药卫生—病原生物学]