小檗碱及其衍生物预防动脉粥样硬化作用机制的研究进展  

Research progress in the mechanism of anti-atherosclerotic effect of berberine and its derivatives

作　　者：谢静岚 洪阁[2] 陶琢 刘玥彤 刘天军[2] Xie Jinglan;Hong Ge;Tao Zhuo;Liu Yuetong;Liu Tianjun(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Biomedical Materials,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin 300192,China;The Second Department of Breast Cancer,Tianjin Medical University Cancer Institute&Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin’s Clinical Research Center for Cancer,Tianjin 300060,China)

机构地区：[1]天津中医药大学,天津301617 [2]中国医学科学院,北京协和医学院生物医学工程研究所,天津市生物医学材料重点实验室,天津300192 [3]天津医科大学肿瘤医院乳腺二科,国家肿瘤临床医学研究中心,天津市"肿瘤防治"重点实验室,天津市恶性肿瘤临床医学研究中心,天津300060

出　　处：《国际生物医学工程杂志》2023年第1期80-87,共8页International Journal of Biomedical Engineering

基　　金：天津市科技支撑计划重点项目(20YFZCSY00570);首都卫生发展科研专项(2022-1-4041);中国医学科学院医学与健康科技创新工程(2021-I2M-1-052)

摘　　要：动脉粥样硬化通常为心血管疾病的基础病因,目前随着饮食习惯和生活环境的改变,已然成为全球范围内日益严重的健康问题,对公共卫生构成巨大的挑战。小檗碱具有清热解毒的作用,是异喹啉类季铵型生物碱,小檗碱及其衍生物具有抗菌、抗炎、抗病毒、抗氧化、降糖、调血脂及预防动脉粥样硬化等作用。从调脂作用、抑制氧化应激与炎症反应、改善血管内皮功能障碍、调节肠道微生物群等角度综述小檗碱及其衍生物预防动脉粥样硬化作用机制的研究进展,以期为减少动脉粥样硬化的发生,改善患者的临床症状,以及小檗碱类药物的深度开发提供理论依据。Atherosclerosis is usually the underlying cause of cardiovascular diseases.With the change in diet structure and living environment,it has become an increasingly serious global health problem,posing a huge challenge to public health.Berberine,also known as flavonidol,is an isoquinoline-type quaternary alkaloid with purgative and detoxifying effects.Berberine and its derivatives have antibacterial,antiviral,anti-inflammatory,antioxidant,hypoglycemic,hypolipidemic,and atherosclerosis prevention effects,etc.Recent research results showed that berberine and its derivatives can play an important role in atherosclerosis prevention through a hypolipidemic effect,anti-oxidative stress and anti-inflammatory activity,improvement of vascular endothelial dysfunction,and regulation of intestinal microbiota.In this review paper,the research progress on the mechanism of action of berberine and its derivatives in the prevention of atherosclerosis was reviewed from the perspectives of a lipid-regulating effect,inhibition of oxidative stress and the inflammatory response,improvement of vascular endothelial dysfunction,and regulation of intestinal microbiota.The aim of this paper is to provide a theoretical basis for reducing the occurrence of atherosclerosis,improving the clinical symptoms of patients,and further developing berberine-based drugs.

关 键 词：小檗碱 结构修饰 动脉粥样硬化 调脂作用 氧化应激与炎症反应 内皮功能障碍 肠道微生物群 

分 类 号：R285[医药卫生—中药学]