Effect of extracellular adenosine triphosphate hydrolysis by apyrase on bleomycin-induced circulating and alveolar mononuclear phagocyte activation and lung inflammation  

作　　者：Chengcheng Su Shengkun Lang Yongqiang Ma Luqing Wei Bin Liu Hongyan Yang Wenjie Ji 

机构地区：[1]Department of Respiratory and Critical Care Medicine,Characteristic Medical Center of Chinese People’s Armed Police Force,Tianjin 300162,China [2]Department of Radiology,Characteristic Medical Center of Chinese People’s Armed Police Force,Tianjin 300162,China [3]Department of Cardiac Intensive Medicine,Characteristic Medical Center of Chinese People’s Armed Police Force,Tianjin 300162,China [4]Institute of Occupational Medicine,Beijing Center for Disease Prevention and Control,Beijing 100020,China

出　　处：《Chinese Medical Journal》2023年第4期494-496,共3页中华医学杂志（英文版）

基　　金：supported by a grant from Tianjin Municipal Science and Technology Committee(No.18JCZDJC12000).

摘　　要：To the Editor:Lung fibrosis is characterized by extracellular matrix accumulation and remodeling of the lung interstitium.Although lung fibrosis has been extensively studied,there is still a lack of effective anti-pulmonary fibrosis drugs at present.The pathogenesis of lung fibrosis involves many aspects in which the lung macrophages play a particularly important role.[1]It has been reported that the manipulation of the monocyte/macrophage phenotype switch might be a potential target for many macrophagemediated inflammatory disorders.In our previous study,mice that were exposed to bleomycin(BLM)showed a dynamic change of mononuclear phagocytes in the circulating system,lung alveoli,and interstitial compartments.The rapid increase of the number of circulating Ly6Chi monocytes after BLM stimulation,followed by the expansion of M2-like alveolar macrophages(AMf)numbers,is closely associated with lung inflammatory response and fibrosis.[2,3]

关 键 词：lung ALVEOLAR inflammation 

分 类 号：R563[医药卫生—呼吸系统]