应重视多囊卵巢综合征患者全生命周期的管理  

Life-cycle management of polycystic ovary syndrome

作　　者：徐阳[1] Xu Yang(Reproductive and Genetic Medical Center of Obstertrics and Gynecology,Peking University First Hospital,Beijing 100034,China)

机构地区：[1]北京大学第一医院妇产科生殖与遗传医疗中心,北京100034

出　　处：《中华医学杂志》2023年第14期1011-1015,共5页National Medical Journal of China

摘　　要：多囊卵巢综合征发病机制复杂,核心特征是下丘脑-垂体-卵巢(HPO)轴功能改变引起的卵巢雄激素过多症以及胰岛素抵抗引起的高胰岛素血症。常见的临床表现包括月经异常、不孕、高雄激素血症、卵巢多囊样改变等,可伴有肥胖、胰岛素抵抗、血脂紊乱等代谢异常,是2型糖尿病、心脑血管疾病和子宫内膜癌发病的高危因素。综合干预措施对于减少多囊卵巢综合征(PCOS)及其合并症的发生至关重要,其中早期识别、提早干预、减少代谢功能障碍是PCOS全生命周期管理的重要手段。The pathogenesis of polycystic ovary syndrome(PCOS)is complex.The core features are ovarian hyperandrogenism caused by hypothalamus-pituitary-ovarian(HPO)axis dysfunction and hyperinsulinemia caused by insulin resistance.Common clinical manifestations include menstrual disorder,infertility,hyperandrogenism,polycystic ovarian morphology,etc.,which can be accompanied by obesity,insulin resistance,dyslipidemia,and other metabolic abnormalities.They are high-risk factors for type 2 diabetes,cardiovascular diseases,and endometrial cancer.Comprehensive intervention measures are crucial to reduce the occurrence of PCOS and its complications.Early identification,early intervention,and reduction of metabolic dysfunction are important means of PCOS life-cycle management.

关 键 词：多囊卵巢综合征 高雄激素血症 胰岛素抵抗 高胰岛素血症 不孕症 

分 类 号：R711.75[医药卫生—妇产科学]