肾结石中草酸钙晶体与细胞相互作用的蛋白质组学研究进展  

Research progress in the proteomics of crystal-cell interaction in pathogenesis of calcium oxalate kidney stones

作　　者：杨瑞[1] 刘春雨[1] 徐勇[1] Yang Rui;Liu Chunyu;Xu Yong(Urolithiasis Treatment Center of Tianjin,the Second Hospital of Tianjin Medical University,Tianjin Institute of Urology,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院尿石症治疗中心,天津市泌尿外科研究所,天津300211

出　　处：《国际生物医学工程杂志》2022年第5期462-467,共6页International Journal of Biomedical Engineering

摘　　要：肾结石因其高发病率,一直以来都是一个全球性的公共卫生问题。引起肾结石最常见的化学成分是草酸钙,其通过肾间质细胞外基质的结晶形成、晶体生长、聚集、晶体与细胞黏附、侵袭等过程形成结石病灶。在这些过程中,晶体与细胞的相互作用至关重要。蛋白质组学已广泛应用于肾结石研究中。主要对肾结石中草酸钙晶体与细胞相互作用蛋白质组学的研究进展进行综述,以期更好地了解肾结石的发病机制。Nephrolithiasis/urolithiasis have long been a global public health problem because of their high incidence.The most common chemical component causing nephrolithiasis/urolithiasis is calcium oxalate,which forms stone lesions through the processes of crystalline formation,crystal growth,aggregation,crystal-cell adhesion,and invasion of the interstitial extracellular matrix of the kidney.In these processes,crystal-cell interactions are crucial.Proteomics has been widely used in the study of nephrolithiasis/urolithiasis.In this paper,the progress of proteomics of calcium oxalate crystal-cell interaction in nephrolithiasis/urolithiasis was reviewed with the aim of better understanding the pathogenesis of kidney stones.

关 键 词：草酸钙 肾结石 蛋白质组学 

分 类 号：R692.4[医药卫生—泌尿科学]