INSL3-RXFP2与两性生殖系统关系研究进展  

Relationship between INSL3-RXFP2 and reproductive system

作　　者：欧文辉[1] 肖文峰 谢新泉 陈凯洪 符马贤 李建宏[1] 段守兴 Ou Wenhui;Xiao Wenfeng;Xie Xinquan;Chen Kaihong;Fu Maxian;Li Jianhong;Duan Shouxing(Second Affiliated Hospital of Shantou University Medical College,Shantou 515041,China;YueBei People's Hospital,Shaoguang 512026,China;Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital),Shenzhen 518000,China)

机构地区：[1]汕头大学医学院第二附属医院小儿外科,汕头515041 [2]粤北人民医院小儿外科,韶关512026 [3]华中科技大学协和深圳医院小儿外科,深圳518000

出　　处：《临床小儿外科杂志》2023年第2期192-196,共5页Journal of Clinical Pediatric Surgery

基　　金：国家自然科学基金青年项目(81801432);广东省自然科学基金(2022A1515010407、2020A1515010135、2018A030307045);广东省科技专项资金("大专项+任务清单")(STKJ2021119);汕头市医疗卫生科技计划项目(汕府科【2020】58-35)

摘　　要：胰岛素样因子3(insulin-like factor 3,INSL3)在两性生殖系统中均有表达,在雄性个体中主要由睾丸间质细胞分泌,在雌性个体中主要由卵泡膜分泌。INSL3的受体为松弛素家族受体2(relaxin family peptide receptor 2,RXFP2),在雄性生殖系统中主要表达于引带细胞、生殖细胞以及睾丸间质细胞,在雌性生殖系统中主要表达于卵细胞及卵泡膜细胞。INSL3-RXFP2通路作用于两性生殖系统,其通路异常与两性生殖系统疾病密切相关。本文将结合最新研究进展,对INSL3-RXFP2与两性生殖系统的关系进行综述。Insulin-like factor 3(INSL3)is predominantly secreted by Leydig's cell in males and theca cells in females.Its specific receptor,relaxin family peptide receptor 2(RXFP2),is expressed in gubernacular,germ and Leydig's cells.RXFP2 is also expressed in ovary and theca cells.Abnormity of INSL3-RXFP2 complex is related to reproductive disease in both males and females.This review summarized the latest researches about the relationship between INSL3-RXFP2 complex and reproductive system.

关 键 词：胰岛素因子3 松弛素家族受体2 隐睾症 雄性生殖系统 雌性生殖系统 

分 类 号：R339.2[医药卫生—人体生理学]