Evaluation of Application of Smear Combined with XpertMTB/RIF Test in Early Diagnosis and Drug Resistance Screening of Tuberculosis in Primary Tuberculosis Designated Hospitals  

涂片联合xpertMTB/RIF检测对基层结核病定点医院肺结核早期诊断和耐药筛查中的应用评价

作　　者：XU Zhiming LI Jing LU Qingping HUANG Jingjing WANG Long WANG Li 

机构地区：[1]Qionghai Center for Disease Control and Prevention, Qionghai Hainan 571400, China [2]Qionghai Name Hospital, Qionghai Hainan 571400, China [3]Hainan Center for Disease Control and Prevention, Haikou 570102, China

出　　处：《外文科技期刊数据库(文摘版)医药卫生》2021年第12期1142-1145,共7页

摘　　要：Objective: to apply and evaluate the practical application value of xpertMTB/RIF detection technology in the diagnosis of related diseases and follow-up treatment, and to evaluate the reliability of the diagnosis of tuberculosis and the safety of the follow-up use of rifampicin in primary units. Methods: xpertMTB/RIF test was performed on smear-positive tuberculosis patients in Qionghai city, Hainan Province from 2015 to 2019. Sputum culture was performed on rifampicin-resistant patients and negative patients at the same time, and the sputum was sent to the provincial reference laboratory for drug sensitivity test and strain identification. From 2015 to 2019, sputum and other body fluids samples of suspected tuberculosis patients at the outpatient clinic of Qionghai City, Hainan province. Results: according to the traditional drug sensitivity test and strain identification as the gold standard, a total of 48 tuberculosis patients were detected from 60 smear-negative sputum specimens of children and 66 other body fluids of children and adults. XpertMTB /RIF detected drug resistance and negative sputum samples in 65 samples. Through strain identification, the traditional drug sensitivity test showed rifampicin resistance in 43 cases, multidrug resistance in 4 cases, and non-tuberculosis mycobacterium (NTM) in 16 cases. XpertMTB /RIF has higher sensitivity to mycobacterium tuberculosis than smear microscopy and Rifampicin resistance to xpertMTB/RIF. Conclusion: xpertMTB/RIF test just need a simple operation can be very precise inspection data as a result, further analysis can even get to rifampin resistance in patients with specific conditions, for detection of mycobacterium tuberculosis (MTB) is the sensitivity of the ideal, can be used for tuberculosis at the grass-roots level in our country fixed-point hospital.

关 键 词：mycobacterium tuberculosis xpertMTB/RIF rifampicin resistance tuberculosis diagnosis 

分 类 号：R521[医药卫生—内科学]