人参二醇组皂甙对庆大霉素性肾损伤的治疗作用  

Mechanism of Treatment with Panaxadiol Saponins on Renal Injury by Gentamicin

作　　者：刘国红[1] 孙芸[1] 杨继要[1] 

机构地区：[1]郑州大学基础医学院组织学与胚胎学教研室,河南郑州450052

出　　处：《河南职工医学院学报》2007年第3期198-200,共3页Journal of Henan Medical College For Staff and Workers

摘　　要：目的探讨人参二醇组皂甙(PDS)治疗庆大霉素(GM)性肾损伤的机制。方法建立GM性肾小管细胞损伤模型,MTT法观察PDS对肾小管细胞增殖的影响,生化法检测PDS对肾小管细胞内SOD、MDA含量的影响。结果PDS可促进GM损伤肾小管细胞的增殖,显著降低MDA含量,提高SOD活性(P<0.05)。结论PDS可能通过促进肾小管细胞的增殖和抑制脂质过氧化反应,加快自由基的清除,从而减轻庆大霉素性肾小管损伤。Objective To clarify the mechanism of PDS in treating renal injury by GM. Methods The influence of PDS on the proliferation of renal tubular cells were observed by MTT staining method.The influence of PDS on SOD,MDA in renal tubular cells injured by GM were observed by biochemical method. Results The treatment of PDS promoted the proliferation of renal tubular cells injured by GM,obviously decreased the content of MDA and increased the activity of SOD. Conclusion PDS may promote the proliferation of renal tubular cells injured by GM,inhibit perioxide reaction,accelerate the elimination of OFR and then alleviate renal injury by GM.

关 键 词：人参二醇组皂甙 肾小管细胞 脂质过氧化 增殖 

分 类 号：R285.6[医药卫生—中药学]