柴胡止血液对人工性周期大鼠置器后子宫内膜内皮生长因子动态变化的影响  

The dynamic regular patterns of VEGF in IUD located rats after Chaihu hemostatic affusion

作　　者：周宜[1] 陈钢[1] 沈映君[1] 解宇环[1] 

机构地区：[1]成都中医药大学药理学教研室,610075

出　　处：《四川生理科学杂志》2007年第3期99-101,共3页Sichuan Journal of Physiological Sciences

基　　金：国家自然科学基金资助项目;编号:A30171134

摘　　要：目的:研究柴胡止血液影响安放IUD后大鼠性周期内子宫组织内皮生长因子(vascular endothelial growth factor,VEGF)动态变化的规律,进一步明确VEGF在IUD出血副反应中的作用,为临床治疗提供新的思路和方法。方法:观测安放Cu-IUD大鼠在人工性周期的不同时相,子宫组织VEGF含量的动态变化以及柴胡止血液对其产生影响。结果:安放IUD后,VEGF在周期前期有所升高,而在周期后期有所降低,柴胡止血液能通过调节平衡作用来对抗安放IUD引起的变化。结论:安放IUD后,对大鼠子宫组织VEGF的动态变化产生了影响,而柴胡止血液能对抗安放IUD所造成的影响。Objective:To seek for the dynamic regular patterns of VEGF,after Chaihu hemostatic affused in the rats whose uterus were located by IUD(intrauterine device),finding clearer mechanism of IUD side-effects in order to provide better ideas for clinical treatment.Method:testing dynamic movement of VEGF of Cu-IUD rats' uterus organism in Manual Estrous-cycle and Chaihu hemostatic effects.Results:After located IUD in rats' uterus,VEGF raised in the early cycle,but it lowed in the later cycle.This experiment proved that Chaihu hemostatic could confront movements of uterus organism in which located IUD by accommodating balance effects.Conclusion:After we located IUD in rats' uterus,IUD made effects in the dynamic movements of VEGF of rats' uterus organism,however,Chaihu hemostatic could confront side-effects from the IUD.

关 键 词：宫内节育器 内皮生长因子 雌激素 孕激素 大鼠 

分 类 号：R285.5[医药卫生—中药学]