布诺洛尔和普萘洛尔对β肾上腺素受体阻断作用的比较  

BETA-ADRENERGIC RECEPTOR BLOCKING EFFECT OF BUNOLOL: A COMPARISON WITH PROPRANOLOL

作　　者：童秋声[1] 石米杨[1] 路承彪[2] 姚丽娜 

机构地区：[1]湖北中医学院药理教研室,武汉430061 [2]同济医科大学药学系,武汉430030

出　　处：《中国药理学通报》1991年第6期444-447,共4页Chinese Pharmacological Bulletin

摘　　要：布诺洛尔(10^(-3),10^(-7),10^(-6)mol/L)能使离体兔右心房肌和豚鼠气管条对Iso所致正性变时性和负性变力性作用的量—效曲线平行右移,pA_2为9.3和9.1。布诺洛尔对心脏β_1受体阻断作用比普荼洛尔强约5倍,对气管β_2受体阻断作用比普荼洛尔强约2.6倍,对心脏β_1受体阻断作用比对气管β_2受体阻断作用略强(约1.6倍)。布诺洛尔(1mg/kg)能完全阻断肾上腺素(10μg/kg)所致大鼠降压反应,对利血平化动物血压及心率无明显影响。The effect of bunolol on β-adrenergic receptor of various tissues of animals were reported. The results showed that cumulative dose-response curves of isoprenaline were shifted paratlely to the right by bunolol ( 10-8, 10-7, 10-6mol/L ) on isolated rabbit atrium and guinea pig trachea preparation utilizing isoprenaline as a beta-receptor agonist. In the isolated rabbit right atrium preparation,the pA2 value of bunolol antagonizing the chronotropic action of isoprenaline was 9.3. In the isolated guinea-pig t...

关 键 词：布诺洛尔 肾上腺素Β 受体阻断药 心房 气管 普荼洛尔 pA_2 

分 类 号：R96[医药卫生—药理学]