人参三醇皂甙促进人白细胞介素3的基因表达  

PROMOTING EFFECT OF PANAXATRIOL GINSENOSIDE ON GENE EXPRESSION OF HUMAN INTERLEUKINE-3

作　　者：田志刚[1] 杨贵贞[2] 

机构地区：[1]山东省医学科学院基础医学所,济南250001 [2]白求恩医科大学免疫教研室,长春130021

出　　处：《中国药理学通报》1991年第6期471-473,共3页Chinese Pharmacological Bulletin

摘　　要：应用mRNA麦胚无细胞体系动态地观察了人参三醇皂甙(PTGS)对人淋巴结细胞白细胞介素3(IL-3)基因表达的促进效应。结果表明,PTGS可以明显促进植物血凝素(PHA)活化人淋巴细胞分泌IL-3,最大促进效应达30%,高峰时相为刺激后72h。PTGS+PHA共刺激后细胞浆IL-3mRNA转译IL-3的量明显高于单纯PHA组,最大促进效应为40%,高峰时相为刺激后60h。从而首次证明PTGS促进了IL-3基因表达,使IL-3基因表达效能增强,最终促进了IL-3合成。Promoting effect of panaxatriol ginsenoside ( PTGS ) on inter-leukine-3(IL-3 ) induction of phyto-hemagglutinin ( PHA ) stimulated human lymph node cells was observed. The results showed that PTGS enhanced the IL-3 production on each time of IL-3-induction kinetics, maximally by 30% ( 72h ) . Furthermore, it was observed that IL-3 mRNA from PHA+PTGS-stimulated lymph node cells translated more IL-3 than PHA-stimulated lymph node cells on each time of IL-3 mRNA-induction kinetics, maximally by 40% ( 60h ) , u...

关 键 词：白细胞介素3 MRNA 人淋巴结细胞 人参三醇皂甙 基因表达 

分 类 号：R96[医药卫生—药理学]