离子浓度对离体大鼠心脏再灌注性心律失常的影响  

INFLUENCES OF PERFUSATE ION CONCENTRATION ON REPERFUSION ARRHYTHMIAS IN LANGENDORFF HEART OF RATS

作　　者：李玉龙[1] 傅绍萱[1] 李蕴山[1] 

机构地区：[1]河北医学院基础医学研究所药理室

出　　处：《中国药理学通报》1989年第2期95-97,共3页Chinese Pharmacological Bulletin

摘　　要：用正交设计方法研究发现在Langendorff大鼠心脏,灌流液中低钾、高钙、低镁所致再灌注性室颤发生率最高:钾、钙离子间交互作用也显著影响再灌注性室颤发生率和潜伏期。因此,可认为灌流液中钾、钙、镁离子的适宜比例是诱发Langendorff大鼠心脏再灌注性心律失常模型的重要因素之一。Using method of orthogonal design we observed that low K+,high Ca2+ & low Mg2+ in perfusate produced the peak incidence of reperf-usion-indaced ventricular fibrillation & introduction of K+ & Ca2+ significantly affected the incidence & pnset of it, The appropriate prop-ortion of K+, ea2+ & Mg2+ in perfusate is the important effecting factor of reperfusion-induced arrhythmias in Langendorff heart of rats.

关 键 词：Langendorff大鼠心脏 再灌注心律失常 钾离子 钙离子 镁离子 

分 类 号：R96[医药卫生—药理学]