粉防己碱对麻醉兔心内传导系统的影响  

EFFECTS OF TETRANDRINE ON THE HEART CONDUCTION SYSTEM IN ANESTHETIZED RABBITS

作　　者：李贵荣[1] 方达超[1] 吕富华[1] 

机构地区：[1]同济医科大学药理教研室

出　　处：《中国药理学通报》1989年第4期217-220,共4页Chinese Pharmacological Bulletin

摘　　要：在麻醉兔观察了粉防已碱对心内传导功能的影响,粉防已碱8mg/kg iv后10min,明显延长兔SACT、SNRT和SNRTc,使SNRTI增大,说明其对窦房结传导功能和自律功能有显著的抑制作用。粉防已碱恒速iv 3～15mg/kg,剂量依赖性地抑制房-室传导,使HBE A-H和ECG P-R延长,但对H-V和V波无明显影响,这与奎尼丁不同。结果表明粉防已碱只抑制室上性传导,对室内传导无影响。Tetrandrine, a bis-benzy 1-i soqui noline alkaloid isolated from Radix Stephania tetrandra S. Moor, was proved to be a calcium antagonist. Its effects upon the heart conduction system were investigated in anesthetized rabbits. Tetrandrine 8 mg/kg iv could prolong the sino-atrial conduction time & the sinus node recovery time from 50 ± 13 ms & 286± 36 ms to 75±19 ms ( n= 8 , P<0.0l) & 393±57 ms (P<0.01) respectively. Tetrandrine 3-15 mg/kg iv lengthened the His-bundle electrogram A-H & electrocardiograph ...

关 键 词：粉防己碱 奎尼丁 心脏传导系统 希氏束电图 

分 类 号：R96[医药卫生—药理学]