~3H-小檗碱在家兔及小鼠体内的药代动力学研究  

PHARMACOKINETIC STUDY OF ~3H-BERBERINE IN RABBITS & MOUSE

作　　者：熊程亿 施绪保[2] 代宗顺[3] 方达超[4] 

机构地区：[1]武汉冶金医学专科学校药理教研室,430080 [2]北京协和医院核医学科 [3]同济医科大学临床药理研究室 [4]同济医科大学药理教研室,武汉430030

出　　处：《中国药理学通报》1989年第5期-,共4页Chinese Pharmacological Bulletin

摘　　要：~3H—小檗碱家兔ig、iv后,血药时程曲线符合二室模型。动力学参数:T1/2β为35.3±1.3h(ig)和35.8±2h(iv),Vd为20±3L/kg(ig)和22.1±1.7L/kg。该药吸收快,分布广泛。肺中浓度最高,其次为肝、脾、肾、心。血浆蛋白结合率为38±3％。大鼠6d内从尿和粪中排泄分别为73％和10.9％。尿液排泄中以原形药物为主,并有代谢产物。After ig and iv 3H-berberine in rabbits, the plasma radioactivity-time cure was found to be 2-compartment open model. The pharma-cokinetic parameters were: T1/2B 35 .3±1 .3h ( ig ) and 35.8 ± 2.0h (iv), Vd 20 ±3 L/kg(ig) & 22.1±1.7 L/kg ( iv ) . 3H-berberine was rapidly absorbed & taken up by various organs . The highest radioactivity was found in lung, followed by liver, spleen & heart. The rate of binding with plasma protein was 38 ± 3 % . In 6 d cumulative excretion of radioactivity was 73% of total dose...

关 键 词：小檗碱 动力学 分布 排泄 

分 类 号：R96[医药卫生—药理学]