异丙肌苷对小鼠免疫功能的增强作用  

POTENTIATING EFFECT OF ISOPRINOSINE ON IMMUNE RESPONSES IN MICE

作　　者：林志彬[1] 马莉[2] 夏冬[1] 

机构地区：[1]北京医科大学药理学教研室,100083 [2]北京医科大学基础医学专业82级

出　　处：《中国药理学通报》1989年第5期-,共5页Chinese Pharmacological Bulletin

摘　　要：在正常小鼠和注射环磷酰胺所致的免疫功能抑制的小鼠,异丙肌苷)25,50,100mg/kg,ip)能显著促进溶血素生成;增加空斑形成细胞数;增强二硝基氯苯所致迟发型皮肤超敏反应。在16月龄老年小鼠,异丙肌苷(2.5mg/kg,ip)可使减少的空斑形成细胞数增加至接近3月龄小鼠的水平,加大剂量作用反减弱或使空斑形成细胞数显著减少。体外试验,异丙肌苷(5,10,20mg/L)可显著增强刀豆素A诱导的C57 BL/6J小鼠的淋巴细胞增殖反应,并使16月龄老年小鼠低下的刀豆素A诱导的淋巴细胞增殖反应明显恢复。Isopinosine (ISO, 25·100 mg/kg·d-1ip for 4 or 5d) significantly increased the production of serum hemolysin-and spleen plaque forming cell ( PFC) in normal mice immunized with SRBC. The same result was observed in immunosuppressive mice induced by cy clophospha-mide. In 16 month aged mice, ISO (ip for 5 d) showed potentiating effect on anti-SRBC PFC response at the dose of 2 .5 mg/kg, no significant effect at the dose of 5 .0 mg/kg, and inhibiting effect at the dose of 25 and 100 mg/kg respectively. 1SO(25,...

关 键 词：异丙肌苷 环磷酰胺 溶血素 空斑形成细胞 迟发型皮肤 超敏反应 淋巴细胞增殖反应 老年免疫缺陷 

分 类 号：R96[医药卫生—药理学]