甲基莲心碱对大鼠心电图和蟾蜍坐骨神经动作电位的影响  

EFFECTS OF NEFERINE ON RAT ECG & THE SURFACE POTENTIAL OF TOAD SCIATIC NERVE

作　　者：李贵荣[1] 钱家庆[1] 吕富华[1] 

机构地区：[1]同济医科大学药理教研室

出　　处：《中国药理学通报》1989年第5期-,共3页Chinese Pharmacological Bulletin

摘　　要：在麻醉大鼠观察了恒速iv甲基莲心碱对ECG的影响,并与奎尼丁和粉防己碱进行了对比性研究。甲基莲心碱对大鼠ECG的影响与奎尼丁相似,剂量(2～40mg/kg)依赖性地延长P-R和Q-T,使QRS增宽;粉防己碱不增宽QRS。结果显示甲基莲心碱作用机理与奎尼丁相似,不同于粉防己碱。甲基莲心碱与奎尼丁都可依浓度抑制蟾蜍坐骨神经APA,二者作用强度相近。Neferine, an alkaloid, isolated form Nelumbo nucifera Gaertn, has antiarrhytbmic effect. The present report deals with its action on the ECG in rat & the surface potential of toad sciatic nerve. Neferine could prolong ECG, P-R & Q-T intervals, and widen QRS in a dose-dependent manner, The effects are similar to quini-dine, and dissimilar to tetrandrine. The inhibitory effects of neferine & quinidine on the surface potential of toad sciatic nerve are similar in potency.

关 键 词：甲基莲心碱 大鼠心电图 奎尼下 粉防己碱 

分 类 号：R96[医药卫生—药理学]