格列齐特缓释片的研制及体外释放度考察  

Preparation and Dissolution of Gliclazide Sustained Release Tablets in Vitro

作　　者：赵丽华[1,2,3] 胡容峰[1,2] 李华[1] 李嘉煜[1] 李师[1] 梅康康[1] 

机构地区：[1]安徽省现代中药研究中心 [2]安徽中医学院药剂教研室,合肥市230038 [3]武警安徽总队医院药械科,合肥市230041

出　　处：《中国药房》2006年第18期1382-1384,共3页China Pharmacy

摘　　要：目的;制备格列齐特缓释片并考察其体外释放度。方法采用混合骨架材料制备格列齐特缓释片;参照进口格列齐特缓释片标准,采用紫外分光光度法,以pH7.4磷酸盐缓冲液900ml为溶剂,桨法测定本品释放度,并与参比制剂进行比较。结果所得缓释片体外释放度符合一级动力学规律,释放曲线经相似因子(f2)判断,与参比制剂相似。结论本品处方工艺稳定、重现性好,体外累积释放度符合要求。OBJECTIVE:To prepare gliclazide sustained release tablets,and to evaluate its dissolution in vitro.METHODS:Mixed matrix materials was used to prepare the tablet.According to the standard of imported Gliclazide sustained release tablets,the dissolution was determined by UV-absorption spectrometry in release medium of900ml of phosphate buffer with pH value of7.4(paddle method).The results were compared with those of the reference preparation.RESULTS:The dissolution of the prepared tablet in vitro accorded wit...

关 键 词：格列齐特缓释片 制备 混合骨架材料 释放度 

分 类 号：TQ463.53[化学工程—制药化工]