葛根素注射液对急性血淤模型大鼠血液流变学及血小板聚集的影响  

Effect of puerarin injection on platelet aggregation in acute blood-stasis model rats

作　　者：潘洪平[1] 杨嘉珍[1] 李吕力[1] 易菲[1] 黄作群[1] 黄开文[1] 

机构地区：[1]广西壮族自治区人民医院,广西南宁530021

出　　处：《中国医院药学杂志》2005年第1期9-11,共3页Chinese Journal of Hospital Pharmacy

基　　金：广西壮族自治区卫生厅医药卫生科研课题(编号:Z2001072)

摘　　要：　目的:观察葛根素注射液对急性血淤模型大鼠血小板聚集的影响。方法:给大鼠注射大剂量盐酸肾上腺素和施以冰水浸 泡,制作急性血淤模型大鼠;采用全自动血流变学仪测定不同切变率的全血粘度、血浆粘度、血液屈服应力和红细胞聚集指数等指 标;以比浊法测定各组的血小板最大聚集率。结果:急性血淤模型大鼠的血液流变性呈异常改变,血小板聚集明显增高,葛根素注 射液对异常改变的血流变学和血小板聚集均有明显的改善作用。结论:葛根素注射液可明显改善急性血淤模型大鼠的血液流变学 作用和抑制异常增高的血小板聚集功能,且呈现一定的量效关系。OBJECTIVE To observe the effect of puerarin injection on platelet aggregation in acut e blood-stasis model rats. METHODS The acute blood-stasis model rats were made by soaked ice water afer injected a drenaline hydrochloride in a major dose.The viscosities of whole blood and plasm a,blood yield stress and erythrocyte aggregation in the acute blood-stasis mode l rats were measured with Auto-Viscometer,and the maximum rate of platelet aggr egation in all groups were measured by turbidimetry. RESULTS P...

关 键 词：葛根素注射液 急性血淤模型 大鼠 血液流变学 血小板聚集 

分 类 号：R285[医药卫生—中药学]