手性配体立体选择性萃取分离扁桃酸对映体  

Enantioselective Separation of Mandelic Acid Enantiomers by Chiral Ligand

作　　者：唐课文[1] 陈国斌[1] 周春山[2] 

机构地区：[1]湖南理工学院化学化工系,岳阳414000 [2]中南大学化学化工学院,长沙410083

出　　处：《无机化学学报》2004年第3期339-344,239,共7页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金资助项目(No.20376085);湖南省自然科学基金资助项目(No.03JJY3020);湖南省教育厅重点资助项目(No.03A014)。

摘　　要：Based on chiral ligand exchange, the distribution behavior of mandelic acid enantiomers in the two-phase system containing copper ion(Ⅱ)(Cu2+) and N-n-dedecane-L-hydroxyproline (L), was studied. At different pH, the partition of Cu2+ in the two-phase system containing N-n-dedecane-L-hydroxyproline, was investigated. The formation constant of binary cpmplex(Li2Cu) was obtained by regression. The influence of pH, concentrations of Cu2+ and chiral ligand, and solvents on partition coefficients(K) and separation factor(α), was discussed. The experimental results show that Li forms more stable ternary complex with D-mandelic acid than with L- mandelic acid. There is a large influence of pH on K and α. At low pH values (<3.5), formation of binary complexes is thermodynamically unfavourable. K and α are best when pH values are above 3.5 and the molar ratio of chiral ligand to Cu2+ is 2:1. At the same time, solvents influence K and α very much.Based on chiral ligand exchange, the distribution behavior of mandelic acid enantiomers in the two-phase system containing copper ion(Ⅱ)(Cu2+) and N-n-dedecane-L-hydroxyproline (L), was studied. At different pH, the partition of Cu2+ in the two-phase system containing N-n-dedecane-L-hydroxyproline, was investigated. The formation constant of binary cpmplex(Li2Cu) was obtained by regression. The influence of pH, concentrations of Cu2+ and chiral ligand, and solvents on partition coefficients(K) and separatio...

关 键 词：配体交换 萃取 手性分离 扁桃酸对映体 

分 类 号：O658.2[理学—分析化学]