知母皂甙元对东莨菪碱所致学习记忆障碍和脑胆碱乙酰转移酶活力降低的影响  

The Effects of ZMS on Learning and Memory Ability and Brain Choline Acetyltransferase in Scopolamine-induced Mouse Model

作　　者：陈勤[1] 胡雅儿[1] 夏宗勤[1] 

机构地区：[1]上海第二医科大学,上海200025

出　　处：《中药材》2001年第7期496-498,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:观察知母活性成分知母皂甙元(ZMS)对学习记忆和脑中胆碱乙酰转移酶(ChAT)活性的影响.方法:腹腔内一次注射东莨菪碱建立小鼠拟痴呆模型,用避暗法及跳台法测定学习记忆能力,用3H-乙酰辅酶A掺入法测定脑组织ChAT活性.结果:ZMS可使东莨菪碱拟痴呆小鼠在学习记忆实验中的错误次数明显减少,潜伏期显著延长,并能显著增强脑内ChAT活性.结论:ZMS能够提高东莨菪碱拟痴呆小鼠的学习记忆能力,增强脑内ChAT的活性,但是,由于ZMS提高ChAT活性没有明显的量效关系,而且Tacrine也有类似作用,所以很可能不是直接提高ChAT活性,而是通过提高脑M受体密度实现的.Objective: To observe the effects of ZMS on learning and memory abillity and on brain choline acetyltransferase activity.Methods: A single intraperitoneal injection of scopolamine was used to establish a dementia mouse model.The learning and memory a-bility was detected by step-through and sted-down tests. And the choline acetyltransferase activity in brain was determined by 3 H-acetyl-CoA incorporation analysis. Results: ZMS could significantly reduce wrongness frequences, prolong incubation period of scop...

关 键 词：知母皂甙元 拟痴呆模型 学习记忆 胆碱乙酰转移酶 

分 类 号：R285[医药卫生—中药学]