(3R,5R)-3,5-二羟基-6-取代己酸不对称合成研究进展  

New Developments in the Asymmetric Synthesis of (3R,5R)-3,5- Dihydroxyl-6-substituted Hexanoic Acid

作　　者：陈万锁[1] 陈志荣[1] 

机构地区：[1]浙江大学联合化学反应工程研究所,杭州310027

出　　处：《有机化学》2004年第2期140-149,114,共11页Chinese Journal of Organic Chemistry

摘　　要：概述近 2 0年来 ( 3R ,5R) 3 ,5 二羟基 6 取代己酸不对称合成进展 ,并提出其研究方向 .The recent progress in the asymmetric synthesis of (3 R,5R ) 3,5 dihydroxyl 6 substituted hexanoic acid is reviewed, using chiral pool reaction, chiral auxiliary reaction, chiral reagent and catalyst. The review emphasizes the catalytic chiral reduction using 2,2′ bis(diphenylphosphino) 1,1′ binaphthyl (BINAP) Ru(II) and catalytic chiral hydroboration reaction with chiral boranes.

关 键 词：(3R 5R)-3 5-二羟基-6-取代己酸 不对称合成 进展 

分 类 号：O621.2[理学—有机化学]