核糖核酸抗肝纤维化的实验与临床研究  

Experimental and Clinical Studies of the Effects of Ribonucleic Acid on Antihepatic Fibrosis

作　　者：侯世荣[1] 凌树森[2] 周晓军[2] 孙其山[3] 丁琦[3] 吴超[1] 张泰和[2] 

机构地区：[1]南京大学医学院附属鼓楼医院,210008 [2]南京军区南京总医院 [3]淮阴市传染病院

出　　处：《江苏医药》1998年第12期860-862,共3页Jiangsu Medical Journal

摘　　要：为研究核糖核酸（RNA）抗肝纤维化的作用，用二甲基亚硝胺（DMN）诱发大鼠肝纤维化，由光镜和电镜检查结果，RNA治疗组肝细胞坏死、变性及胶原纤维增生程度较病理对照组及辅酶Q10治疗组均明显减轻。随机对照用RNA和辅酶Q10分别治疗慢性肝炎（CH）伴／不伴代偿期肝硬化（HC）93例及92例，疗程3个月。结果RNA组改善肝功能和降低血清三型前胶原（PCI）和透明质酸（HA）的疗效均明显优于辅酶Q10组。肝活俭显示，RNA治疗后肝脏炎症活动度和胶原纤维含量较治疗前明显减轻，而辅酶Q10治疗者反有加重。实验与临床研究结果一致，说明RNA有抗肝纤维化作用。The effects of ribonucleic acid (RNA) on antihepatic fibrosis were studied experiment on rats hep-atic fibrosis induced by intraperitoneal injection of dimethylnitrosoamine revealed that the degree of hepatocyticnecrosis and degeneration and the quantity of collagenosis were rather mild in the RNA treated group as comparedwith the pathological control and co-enzyme Q10 treated groups under microscopical and ultrastructural examina-tions. A randomized controlled clinical study was carried out in 185 cases of...

关 键 词：慢性肝炎 肝纤维化 核糖核酸 

分 类 号：R965[医药卫生—药理学]