儿童期尿骨吸收指标—羟脯氨酸与叠交联检测分析  

Urinary bone resorption markers——hydroxproline and crosslaps analysis in children.

作　　者：陆国强[1] 王伟[1] 崔贻芬[1] 付曼芬[1] 曾畿生[1] 王德芬[1] 

机构地区：[1]上海第二医科大学附属瑞金医院儿科实验室

出　　处：《上海医学》1998年第5期19-20,共2页Shanghai Medical Journal

摘　　要：目的：分析健康儿童、青春发育前后期及垂体性侏儒症病人的尿骨吸收指标——羟脯氨酸和叠交联的变化。方法：采用改良的氯胺Ｔ比色测定和酶联免疫法。结果：健康儿童各年龄组间尿骨吸收指标无明显差异，性别、青春发育前后期及垂体性侏儒症患儿治疗前后尿骨吸收指标均有明著差异。结论：尿骨吸收指标在儿童期检测，需考虑性别及青春发育的影响因素并提示在早期观察药物疗效中有一定的临床意义。Objective: To investigate the sgniificance of changes of urinary bone resorption markers (hydroxproline and crosslaps) in normal children with various ages,during pre-and puberty,also in patients with growth hormone deficiency(GHD).Methods:Using modified chloramine T assay for hydroxyproline and ELISA method for crosslaps.Results:No significant difference in levels of urinary hydroxproline and crosslaps were. shown in various age groups of normal children,but significant difference was found between pre and...

关 键 词：羟脯氨酸 叠交联 垂体性侏儒症 

分 类 号：R584.21[医药卫生—内分泌]