干燥综合征合并肾小管性酸中毒  

Sjgren syndrome accompanied by renal tubular acidosis

作　　者：任红[1] 陈楠[1] 陈晓农[1] 傅秀兰[1] 郝翠兰[1] 江永娣[1] 董德长[1] 

机构地区：[1]上海第二医科大学附属瑞金医院肾脏科

出　　处：《上海医学》1998年第5期28-30,共3页Shanghai Medical Journal

摘　　要：目的：结合实验检测及肾脏病理，了解干燥综合征中肾小管性酸中毒的发生情况。方法：对我科１９８８年１月～１９９７年１月收治的４０例干燥综合征（ＳＳ）肾脏损害患者进行常规、免疫学、肾小管功能及肾活检等检查。结果：２８／４０为远端肾小管性酸中毒（ｄＲＴＡ），１３／２８合并其他自身免疫性疾病，１８／２８合并低钾性麻痹，３／２８合并肾性尿崩症。６７．９％患者为高免疫球蛋白Ｇ血症，５７．１％和５０％患者抗ＳＳ－Ａ、抗ＳＳ－Ｂ抗体阳性。１１／２８行肾活检，发现肾小管间质中有大量淋巴细胞和浆细胞浸润，部分小管萎缩，间质纤维化。２０／２８例患者用激素治疗，４／２８例合并用环磷酰胺治疗。结论：ＳＳ合并ｄＲＴＡ常见，长期中、小剂量激素治疗可减少肾小管及间质损害。Objective:To further study the occurrence of RTA in Sjogren syndrome with combind laboratory examinations and renal pathology. Methods:From 1988.11997.1 40 patients of SS with renal impairment were analyzed by routine measures, immunoassay, tubular functional tests and renal biopsy,etc. Results:28/40 were with dRTA, 13/28 with autoimmune diseases, 18/28 with hypokalemic paralysis, 3/28 with renal diabetes insibidus.Hypergammaglobulinemia was observed in 19 of 28(679%).About 571% and 50% patients reveale...

关 键 词：干燥综合征 肾小管性酸中毒 

分 类 号：R442.8[医药卫生—诊断学]