Synthesis and Crystal Structure of (2S,5S)-1-Aza-2- (2-pyridyl)-3-oxa-4,4-diphenylbicyclo [3.3.0] Octane  

作　　者：LU Jun JI Shun-Jun QIAN Rong JIANG Zhao-Qin ZHANG Yong LANG Jian-Ping 

机构地区：[1]School of Chemistry and Chemical Engineering,Suzhou University,Jiangsu 215006,China [2]Key Lab of Organic Synthesis of Jiangsu Province,Suzhou University 215006,China

出　　处：《Chinese Journal of Structural Chemistry》2004年第6期527-530,共4页结构化学（英文）

基　　金：the National Natural Science Foundation of China (No. 20172039)

摘　　要：The title compound (C23H22N2O) 3 has been synthesized by the reaction of (S)- (-)-1,1-diphenyl-2-pyrrolidinemethanol 1 with 2-pyridinecarboxaldehyde 2 in refluxing benzene catalyzed by TsOH, and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group P212121 with a = 8.4747(8), b = 10.8829(10), c = 19.777(2) , Mr = 342.43, V =1824.0(3) 3, Dc = 1.247 g/cm3, Z = 4, m = 0.077 mm-1 and F(000) = 728. The structure was solved by direct methods and refined by full-matrix least-squares techniques to the final R = 0.0497 and wR = 0.0927.The title compound (C23H22N2O) 3 has been synthesized by the reaction of (S)- (-)-1,1-diphenyl-2-pyrrolidinemethanol 1 with 2-pyridinecarboxaldehyde 2 in refluxing benzene catalyzed by TsOH, and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to orthorhombic, space group P212121 with a = 8.4747(8), b = 10.8829(10), c = 19.777(2) , Mr = 342.43, V =1824.0(3) 3, Dc = 1.247 g/cm3, Z = 4, m = 0.077 mm-1 and F(000) = 728. The structure was solved by direct methods and refined by full-matrix least-squares techniques to the final R = 0.0497 and wR = 0.0927.

关 键 词：SYNTHESIS crystal structure (2S 5S)-1-aza-2-(2-pyridyl)-3-oxa-4 4- diphenylbicyclo [3.3.0] octane 

分 类 号：O626.32[理学—有机化学]