云南美登木内生真菌Chaetomium globosum Ly50′菌株的抗菌活性成分研究  

Antimicrobial Components of the Endophytic Fungal Strain Chaetomium globosum Ly50′ from Maytenus hookeri

作　　者：倪志伟[1] 李国红[1] 赵沛基[1] 沈月毛[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室

出　　处：《天然产物研究与开发》2008年第1期33-36,共4页Natural Product Research and Development

基　　金：国家杰出青年基金项目(30325044);国家自然科学基金项目(30430020)

摘　　要：从云南美登木叶中分离筛选到具抗菌活性的内生真菌Chaetomium globosum Ly50′菌株,利用活性追踪法在其发酵产物中分离到抗橙色青霉和抗结核分枝杆菌的化合物,经ESI-MS、NMR等波谱数据确认该活性成分为球毛壳甲素,chaetoglobosin A和球毛壳乙素chaetoglobosin B。首次发现chaetoglobosin B具有抗结核分支杆菌活性。The fungal strain Chaetomium globosum Ly50′ was isolated from the leaf of Maytenus hookeri and was active against Penicilium avellaneum UC-4376 and Mycobacterium tuberculosis.Activity-guided isolation led two compounds from the secondary metabolites.They were determined to be chaetoglobosin B (1) and chaetoglobosin A (2) on the basis of spectroscopic analysis.Chaetoglobosin B possesses obvious antituberculosis activity.

关 键 词：内生真菌 云南美登木 球毛壳菌 chaetoglobosin A chaetoglobosin B 

分 类 号：R915[医药卫生—微生物与生化药学]