锁阳PartⅢ对环磷酰胺致免疫抑制小鼠免疫功能的影响  

Study on the Effect of Part Ⅲ from Cynomorium songaricum on Immunosuppressive Mice Induced by Cyclophosphamide

作　　者：张汝学[1] 贾正平[1] 李茂星[1] 王娟[1] 尹强[1] 罗军德[1] 刘红艳[2] 

机构地区：[1]兰州军区兰州总医院,甘肃兰州730050 [2]陇南市人民医院妇产科,甘肃陇南746000

出　　处：《中药材》2008年第3期407-409,共3页Journal of Chinese Medicinal Materials

基　　金：全军"十一五"面上项目(No.06MB101);兰州军区医药卫生科研基金资助项目(LXH-2005012)

摘　　要：目的:研究锁阳PartⅢ对环磷酰胺致免疫抑制小鼠免疫功能的影响。方法:用环磷酰胺(CTX,100 mg/kg)腹腔注射制备小鼠免疫低下模型,给药组和阳性对照人参皂苷(TSPG)组剂量均为300 mg/kg.d,空白对照组和缺氧模型组给予同体积的蒸馏水,灌胃给药,共7 d。分别从外周血象、免疫器官指数、巨噬细胞吞噬功能和血清溶血素水平等方面进行评价。结果:锁阳水提物PartⅢ可使CTX免疫抑制小鼠的免疫器官指数、巨噬细胞吞噬功能和血清溶血素水平不同程度的升高。结论:锁阳水提物PartⅢ能够增强CTX免疫抑制小鼠的非特异性和特异性免疫功能,对免疫失衡机体具有一定的保护作用。Objective: To study the immunomodulatory effect of Part Ⅲ of Cynomorium songaricum Rupr.on the immunosuppressive mice.Methods: The immunity-deficiency model was induced by intraperitoneal injection of cyclophosphamide(CTX) at the dose of 100 mg/kg in mice; all the animals were divided into normal control group,immunity-deficiency model group,Part Ⅲ treated group(300 mg/kg) and positive control group(TSPG,300 mg/kg).The hemogram of peripheral blood,the index of immune organs,the phagocytosis activity of macr...

关 键 词：环磷酰胺 锁阳 PartⅢ 免疫抑制 

分 类 号：R285[医药卫生—中药学]