放射性^(125)I粒子植入近距离放疗联合化疗治疗晚期肺癌的近期疗效  

Short-term Efficacy of Interstitial Implantation of ^(125)I Seeds Combined with Chemotherapy for Advanced Lung Cancer

作　　者：郑广钧[1] 柴树德[1] 毛玉权[1] 闫卫亮[1] 杨景魁[1] 梁吉祥[1] 

机构地区：[1]天津医科大学第二医院心胸外科,天津300211

出　　处：《中国微创外科杂志》2008年第2期122-124,136,共4页Chinese Journal of Minimally Invasive Surgery

摘　　要：目的探讨CT引导下经皮穿刺和纤维支气管镜(flexible fiberoptic bronchoscope,FFB)直视下种植放射性125I粒子植入近距离内照射治疗晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的近期效果。方法术前临床和活检证实为NSCLC185例,粒子植入联合化疗组(n=121)进行放射性125I粒子植入,处方剂量(priscribed dose,PD)80Gy、长春瑞滨(诺维本)联合顺铂(NP)方案化疗,其中89例通过CT引导经皮穿刺种植,32例在FFB直视下种植粒子。单纯化疗组(n=64)行NP方案化疗。2组治疗后6个月根据CT和FFB检查,比较肿瘤体积,按国际标准判定疗效。结果粒子植入联合化疗组植入粒子后,瘤体接受的平均照射剂量为153.7Gy,匹配周边剂量(matched peripheral dose,MPD)89.6Gy,D9093.5Gy。6个月后粒子植入联合化疗组有效率(CR+PR)为95.0%(115/121),1年累计生存率0.90。单纯化疗组有效率为42.2%(27/64),1年累计生存率0.65,两组差异有显著性(log-rank检验,χ2=5.12,Prob=0.04<0.05)。结论放射性125I粒子植入联合化疗是一种有效的、微创的治疗晚期NSLC的方法,疗效明显高于单纯NP方案化疗的患者。Objective To evaluate the short-term efficacy of interstitial implantation of 125I seeds by using flexible fiberoptic bronchoscope (FFB) guided by CT for advanced non-small cell lung cancer (NSCLC). Methods A total of 185 patients with NSCLC, who were diagnosed clinically and pathologically, were enrolled into this study and divided into two groups. In 125I seeds group (n=121), the patients received interstitial implantation of 125I combined with NP regimen (NVB+DDP) chemotherapy with a prescribed dose (PD)...

关 键 词：非小细胞肺癌 125I粒子 纤维支气管镜 

分 类 号：R734.2[医药卫生—肿瘤]