OA护膝对膝骨性关节炎关节滑液细胞因子影响的实验研究  

Experimental Study of OA Kneepad on Cytokines in Synovial Fluid of Knee Ostearthritis

作　　者：刘献祥[1] 林木南[2] 杜民[3] 李西海[1] 郑良朴[1] 王宇琳[3] 宋明清[3] 吴追乐[1] 陈文列[1] 

机构地区：[1]福建中医学院,福建福州350108 [2]南京军区福州总医院,福建福州350025 [3]福州大学,福建福州350002

出　　处：《福建中医学院学报》2006年第6期18-21,共4页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省自然科学基金重点项目(C0420002);福建省中医药科研重点课题(wzzg0601)

摘　　要：为探讨OA护膝对实验性兔膝骨性关节炎关节滑液细胞因子的影响,将60只日本大耳白兔随机分为6组,分别测定关节滑液IL-1βI、L-6、TNF-α、MMP-3、HA浓度。结果表明OA护膝通过有效抑制细胞因子、调节MMP-3、HA的生物效应来延缓关节软骨的退变。To study the effect of OA kneepad on the cytokines in synovial fluid of knee osteoarthritis.60 rabbits were randomly divided into six groups,and the levels of IL-1β,IL-6,TNF-α,MMP-3,HA in rabbits synovial fluid were determined respectively.The results showed that OA kneepad could delay cataplasia of articular cartilage by inhibiting cytokines and adjusting biological effect of MMP-3,HA.

关 键 词：OA护膝 骨性关节炎 滑液 细胞因子 透明质酸 基质金属蛋白酶 

分 类 号：R684.3[医药卫生—骨科学]