金黄色葡萄球菌超抗原与慢性鼻窦炎鼻息肉发生相关性的研究  

A primary study about the correlation between superantigens produced by Staphylococcus aureus and chronic rhinosinusitis with nasal polyps

作　　者：王明明[1] 张大良[1] 张红萍[1] 王喆[1] 陈雪梅[1] 剪京芬[1] 

机构地区：[1]山东大学第二医院耳鼻咽喉科,济南250033

出　　处：《临床耳鼻咽喉头颈外科杂志》2006年第20期914-916,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨金黄色葡萄球菌(金葡菌)超抗原在鼻息肉发生中的作用。方法:对42例双侧鼻息肉患者(鼻息肉组)、27例单纯慢性鼻窦炎患者(鼻窦炎组)和12例无鼻窦疾病史的鼻外伤患者(对照组)的鼻腔分泌物进行细菌培养;采用酶联免疫吸附试验(ELISA)法检测各组患者的鼻黏膜或息肉组织中的金葡菌超抗原;在组织学上,对苏木精-伊红染色切片进行嗜酸粒细胞计数。结果:鼻腔分泌物中金葡菌阳性率鼻息肉组为7.1%,鼻窦炎组为3.7%,对照组为0,各组间差异均无统计学意义(均P>0.05)。ELISA结果显示:鼻息肉组金葡菌超抗原阳性率为54.76%,鼻窦炎组和对照组阳性率均为0。嗜酸粒细胞计数平均值:鼻息肉组23.94±13.88,鼻窦炎组0.29±0.51,对照组0.08±0.28,3组间均差异有统计学意义(均P<0.05)。鼻息肉组中ELISA结果阳性者嗜酸粒细胞水平比阴性者高,但差异无统计学意义(P>0.05)。结论:金葡菌超抗原与鼻息肉的发生存在相关性,有可能在鼻息肉的致病机制中起重要作用。Objective:To study the role of superantigens produced by Staphylococcus aurous in the pathogenesis of nasal polyps.Method:sinonasal mucus and polyp/mucosa tissue were obtained from sixty-nine patients with chronic rhinosinusitis (42 patients with bilateral nasal polyps, 27 without nasal polyps). Samples from twelve normal subjects were also obtained for comparative negative controls. Mucus specimens were cultured for bacteria. Tissue specimens were assayed by ELISA for staphylococcal exotoxins. In addition,...

关 键 词：金黄色葡萄球菌 超抗原 鼻息肉 嗜酸粒细胞 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]