用离子液体四氟硼酸正丁基吡啶盐作催化剂和反应介质合成3,4-二氢嘧啶-2-酮  

Synthesis of 3,4-dihydropyrimidin-2(1H)-ones using ionic liquid n-butyl pyridinium tetrafluoroborate as a catalyst and medium

作　　者：周美云[1] 李毅群[1] 

机构地区：[1]暨南大学化学系,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2006年第3期435-438,共4页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金(20272018);广东省自然科学基金(04010458;021166);教育部留学回国人员科研启动基金(外教司留2001-498)资助项目

摘　　要：采用离子液体四氟硼酸正丁基吡啶盐([bpy]BF4)作催化剂和反应介质,芳香醛、乙酰乙酸乙酯、尿素进行三组分B iginelli缩合,制备了3,4-二氢嘧啶-2-酮衍生物.结果表明,反应时间短、操作简便、产率60%~70%、不需使用有机溶剂,离子液体可重复使用,对环境友好.Dihydropyrimidiones and their derivatives were synthesized by the Biginelli three component condensation of aromatic aldehydes,ethyl acetoacetate ester and urea(using) room temperature ionic liquid n-butyl pyridinium tetrafluoroborate BF_4 as a(catalyst) and medium.The results showed the protocol has the advantages such as short reaction time,simple procedures,moderate yields,the ionic liquid reusability and benign to environmental without using organic solvent.

关 键 词：离子液体 Biginelli缩合 3 4-二氢嘧啶-2-酮 

分 类 号：O643.32[理学—物理化学]