载NC-1900 MePEG-PLA纳米粒的处方设计、优化及表征(英文)  

Preparation,optimization and characterization of NC-1900 loaded MePEG-PLA nanoparticles

作　　者：胡凯莉[1] 谢月玲[1] 陆伟[1] 蒋新国[1] 

机构地区：[1]复旦大学药学院药剂教研室,上海200032

出　　处：《复旦学报（医学版）》2007年第6期800-805,820,共7页Fudan University Journal of Medical Sciences

基　　金：National Science Foundation of China (30472095);National Basic Research Programof China (973program,2007CB935800)

摘　　要：目的制备载NC-1900的MePEG-PLA纳米粒。方法以溶液聚合法合成不同分子量的MePEG-PLA聚合物为材料,采用复乳溶剂挥发法制备纳米粒,以纳米粒粒径和NC-1900包封率为考察指标,设计正交试验及多元回归分析优化处方与工艺,并对纳米粒进行表征,结合体外泄漏试验筛选出最优的NC-1900纳米粒载体。结果以MePEG3000-PLA44800为材料根据最优处方制得的载NC-1900NPs均匀圆整,平均粒径为(77 ±11) nm,包封率约为(21.40 ±0.10) % ,在pH7.4的PBS溶液和空白血浆中48h NC-1900泄漏率分别小于5%和15%。结论最优处方制得的MePEG3000-PLA44800纳米粒适宜作为NC-1900的载体。Purpose To optimize the preparation of NC-1900 loaded MePEG-PLA nanoparticles(NPs).Methods MePEG-PLA copolymers of different molecular weight synthesized by solvent poly-merization method were used to prepare NC-1900 loaded MePEG-PLA NPs by double emulsion/solvent evaporation method.Orthogonal experimental design and multiple regressions were used to optimize the preparation method with nanoparticle size and NC-1900 encapsulation efficiency(EE) as res-ponse variables.NPs were characterized by particle size ...

关 键 词：复乳溶剂挥发法 NC-1900 MePEG-PLA 纳米粒 

分 类 号：R94[医药卫生—药剂学]