艾滋病患者上消化道黏膜病变特点及相关因素研究  

The Analysis of the Pathological Characteristics of Gastro-mucosa Epithelium in Patients with Acquired Immunodeficiency Syndrome (AIDS) and Relevant Factors

作　　者：金瑞[1] 张斌[1] 刘素贞[1] 吕富靖[1] 李冰[1] 王贞彪[1] 赵景民[2] 孙玉临 吴昊[4] 

机构地区：[1]首都医科大学附属北京佑安医院消化科,100069 [2]中国人民解放军302医院病理科 [3]北京天坛医院电镜室 [4]北京市性病艾滋病诊疗中心

出　　处：《中国消化内镜》2007年第3期10-12,共3页Digestive Disease and Endoscopy

基　　金：北京市科委重点资助项目(D0906003040591)

摘　　要：目的探讨艾滋病患者食管及胃黏膜损害的病变特点。方法研究对象共240例,分为实验组及对照组。实验组包括133例有消化道症状的艾滋病患者,对照组为107例HIV抗体阴性者。实验组所有患者行胃镜检查,并取黏膜组织做光镜及电镜观察,另外使用Warthin-Starry染色判断幽门螺旋杆菌(Hp)感染。同时对镜下可疑病变的食管黏膜进行刷检以检测真菌孢子或者菌丝。对照组病例作以上的相同处理。结果两组间慢性胃炎的发生率未发现差异;实验组133例中有21例检出念珠菌性食管炎。实验组中消化性溃疡(PU)及Hp的检出率(分别为2.26%和19.55%)较对照组为低(分别为21.49%和54.21%),(P<0.005)。胃镜或显微镜下观察,实验组黏膜损害严重。结论艾滋病患者易出现念珠菌性食管炎,消化性溃疡及幽门螺旋杆菌感染的发生率较对照组低,但显微镜下及电镜观察到的慢性胃炎黏膜细胞损伤均较对照组严重。原因可能与艾滋病患者一般CD4+T淋巴细胞计数较少有关。Objective:To investigate the characteristic of pathological changes of gastro-mucosa epithelium in patients with acquired immunodeficiency syndrome (AIDS). Methods: 240 people were divided into 2 groups, which are trial group, including 133 AIDS patients presenting gastrointestinal symptoms, and control group, including 107 people with negative antibody of HIV, respectively. In trial groups all patients were examined by gastroscopy. The gastro-mucosa tissues in these patients obtained by endoscopic biopsy w...

关 键 词：艾滋病 胃黏膜 慢性胃炎 念珠菌性食管炎 幽门螺旋杆菌 

分 类 号：R512.91[医药卫生—内科学]