慢性心力衰竭患儿血浆肾上腺髓质素、C-型利钠肽及心肌作功指数测定  

Changes of plasma levels of adrenodullin,C-type natriuretic peptide and myocardial performance index in children with chronic heart failure

作　　者：段桂琴[1] 丛娟[2] 安金斗[3] 

机构地区：[1]郑州大学第三附属医院儿保科,郑州450052 [2]郑州大学第三附属医院超声科,郑州450052 [3]郑州大学第一附属医院儿科,郑州450052

出　　处：《郑州大学学报（医学版）》2007年第4期694-697,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨慢性心力衰竭(CHF)患儿血浆肾上腺髓质素(ADM)、C-型利钠肽(CNP)浓度和心肌作功指数(Tei指数)的变化。方法:42例CHF患儿,心功能Ⅱ级16例、Ⅲ级14例、Ⅳ级12例,原发疾病为扩张性心肌病12例,先天性心脏病19例,心内膜弹力纤维增生症等其他疾病11例。正常对照组11例。用同位素放射免疫分析法测定2组血浆ADM和CNP含量,超声心动图测定Tei指数、左室射血分数(LVEF)。结果:CHF患儿治疗前血浆ADM和CNP含量高于正常对照组(P=0.000);治疗后血浆ADM和CNP含量均较治疗前降低(P<0.05)。CHF患儿血浆ADM、CNP含量和Tei指数随心功能级别的升高而升高(P<0.05)。心肌病组、先心病组及其他病组间血浆ADM、CNP含量和Tei指数差异无统计学意义(P均>0.05)。CHF组血浆ADM和CNP水平与Tei指数均呈正相关(r分别为0.87,0.59,P均<0.001);与LVEF均呈负相关(r分别为-0.69,-0.48,P均<0.01)。结论:ADM有可能成为评估小儿CHF严重程度和预测CHF预后新的生化指标。Aim:To investigate the changes of plasma adrenodullin(ADM)and c-type natriuretic peptide(CNP)level and the myocardial performance index(MPI)in children with chronic heart failure(CHF).Methods:A total of 42 children with CHF,including 12 cases of dilated cardiomyopathy,19 cases of congenital heart defects,and 11 cases of other heart diseases,were classified,and 16 cases as class Ⅱ,14 as class Ⅲ,and 12 as class Ⅳ.Plasma ADM and CNP levels were measured by radioimmunoassay,and MPI and LVEF were measured by ech...

关 键 词：慢性心力衰竭 小儿 肾上腺髓质素 C-型利钠肽 心肌作功指数 

分 类 号：R725.4[医药卫生—儿科]