HG颗粒对免疫性肝损伤小鼠肝功能的影响  

Effects of HG Keli on liver function of immunological liver injury mice by bacilli calmette guerin and lipopolysaccharide

作　　者：毕红征[1] 杜春燕[1] 黄国钧[2] 

机构地区：[1]郑州大学实验动物中心,郑州450052 [2]成都中医药大学药学院,成都610075

出　　处：《郑州大学学报（医学版）》2007年第4期744-746,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:研究HG颗粒对免疫性肝损伤小鼠肝功能的影响。方法:50只小鼠用卡介苗联合脂多糖腹腔注射,建立小鼠免疫性肝损伤模型,其中4组分别给予HG颗粒高(9g/kg)、中(4.5g/kg)、低(2.25g/kg)剂量及复方鳖甲软肝片(1.5g/kg)灌胃治疗,余10只模型小鼠(模型对照组)和10只未造模小鼠(正常对照组)给予蒸馏水灌胃,1次/d,10d后,检测各组小鼠血清丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)活性。结果:模型对照组小鼠血清ALT、AST活性较正常对照组增高。HG颗粒组血清ALT、AST活性均较模型对照组下降(P<0.05)。结论:HG颗粒具有保护卡介苗联合脂多糖致免疫性肝损伤小鼠肝功能的作用。Aim:To explore the effects of HG Keli on liver function of immunological liver injury mice.Methods:A total of 50 mice were injected visceral by bacilli calmette guerin and lipopolysaccharide to establishe immunological liver injury model,then were divided into 5 groups,4 groups were given 9 g/kg,4.5 g/kg,2.25 g/kg HG Keli and FuFangBieJiaRuanGan tablets(1.5 g/kg)through tube feeding,respectively,and the else 10 mice model were given normal saline.10 mice without injection were the normal control.The avtivit...

关 键 词：HG颗粒 免疫性肝损伤 肝功能 

分 类 号：R285.5[医药卫生—中药学]