脱氢表雄酮对哮喘大鼠血嗜酸粒细胞、IL-4和IFN-γ水平的影响  

Effect of dehydroepiandrosterone on blood eosinophils,interleukin-4,and interferon-gamma serum levels in asthma rats

作　　者：李艳[1] 赵景俊[1] 栾斌[1] 

机构地区：[1]郑州大学第三附属医院儿内科,郑州450052

出　　处：《郑州大学学报（医学版）》2007年第4期732-734,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:观察脱氢表雄酮(DHEA)对哮喘大鼠血嗜酸粒细胞(EOS)数量及IL-4、IFN-γ的水平影响。方法:30只大鼠建立哮喘模型后随机等分为实验组和对照组,每组15只。实验组在给予DHEA前先采血1次,然后用DHEA5mg腹腔注射,每周1次共2次,第3周采血。对照组腹腔注射1mL溶剂,每周1次共2次,第3周采血。计数血EOS,并检测IL-4、IFN-γ浓度。结果:实验组干预前与对照组相比,血EOS数、血清IL-4和IFN-γ浓度差异无统计学意义(P均>0.05);实验组干预后与对照组相比,血EOS数、血清IL-4质量浓度均降低(P均<0.05),血清IFN-γ质量浓度升高(P<0.05)。结论:DHEA参与了哮喘模型大鼠体内的免疫调节,可降低血液中EOS的数量和IL-4水平,提高IFN-γ水平。Aim:To investigate the effects of dehydroepiandrosterone(DHEA)on eosinophil(EOS),interleukin-4(IL-4)and interferon-gamma(IFN-γ)serum levels in asthma rat model.Methods:A total of 30 asthma rat were randomly devided into experiment and control groups,with 15 rats in each group.In experiment group,5 mg DHEA were celiac injected once a week for 2 times in total.Before injection and the third week after injection,the bloods were collected.In control group,the normal saline were celiac injected by the same metho...

关 键 词：脱氢表雄酮 哮喘 大鼠 嗜酸粒细胞 白细胞介素-4 干扰素-γ 

分 类 号：R562.25[医药卫生—呼吸系统]