3-甲氧基二苯胺合成工艺的改进  

Improved Synthesis of 3-methoxydiphenylamine

作　　者：姚建文[1] 

机构地区：[1]烟台大学药学院,山东烟台264005

出　　处：《烟台大学学报（自然科学与工程版）》2007年第3期231-234,共4页Journal of Yantai University(Natural Science and Engineering Edition)

摘　　要：3甲-氧基二苯胺是一种重要的精细化学品,目前工业化生产中存在收率低、纯度不高等问题.对现有的3-甲氧基二苯胺的合成路线进行分析和比较,确定了以间溴苯甲醚和苯胺为原料,将苯胺甲酰化得甲酰苯胺,甲酰苯胺与间溴苯甲醚在无水碳酸钾和铜粉存在下缩合得缩合物,将所得缩合物在碱性条件下水解得到3-甲氧基二苯胺的工艺路线,并对该工艺进行了改进,产品总收率高达80.5%,纯度99.0%以上.新工艺反应收率及产品纯度高、生产成本低,易于进行工业化生产.3-methoxydiphenylamine is an important fine chemica1.However,in the present industrialized production,both the jield and the purity of the prodnct is low.After the analysis and compare of several processes,a novel process of using aniline and m-bromoanisole as initial material is selected and investigated.3-methoxydiphenylamine is synthesized by formylation,condensation and hydrolysis under alkalinious catalyst condition.The new technology has the features of simple process,lower cost and higher yield,the o...

关 键 词：3甲-氧基二苯胺 间溴苯甲醚 2甲-氧基吩噻嗪 合成 

分 类 号：TQ246.31[化学工程—有机化工]